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Diatomaceous earth (DE) will kill squash bug adults and nymphs, but because it will need to be applied to the leaves and stems of plants to be effective, there’s also a chance that it will kill pollinators, like bees and butterflies, as well as other beneficial insects, like ladybugs. If you do apply it to plants, apply it in the early morning or late evening and avoid applying it on or near flowers.

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